Brain Lipids in Synaptic Function and Neurological Disease

by    Prof. Jacques FANTINI              Prof. Nouara YAHI



Brain Lipids in Synaptic Function and Neurological Disease

Clues to Innovative Therapeutic Strategies for Brain Disorders

Authors: Jacques Fantini Nouara Yahi
eBook ISBN: 9780128004920
Hardcover ISBN: 9780128001110
Imprint: Academic Press
Published Date: 3rd July 2015
Page Count: 398 link link


Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.


Key Features

  • Written to provide a "hands-on" approach for readers
  • Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings
  • Step-by-step guide to memorize and draw lipid structures
  • Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique


Neuroscience graduate students, post-doctoral fellows, experienced researchers new to neuroscience, and senior researchers that want technique updates